A 40 year old woman presents to the Emergency Department complaining of vertigo. She describes intermittent episodes that usually last around 2 hours and are associated with a "ringing" in her right ear. She has no significant past medical history. On examination you find she is afebrile with normal cardiovascular and respiratory observations and examinations. You find no focal neurological deficit in her limbs. On cranial nerve examination you find Weber's test lateralises to the left ear. What is the most likely diagnosis?
Meniere's disease is a disorder affecting the inner ear characterised by episodes of vertigo, fluctuating hearing loss, and tinnitus and is associated with a feeling of fullness in the affected ear.
In most people with Meniere's disease, the cause is unknown. There is a general view that abnormal endolymph production and/or absorption resulting in endolymphatic hydrops with swelling of the membranous labyrinth (vestibular system and cochlear duct) may lead to the classic symptoms of Meniere's disease.
The diagnosis of Meniere's disease is most commonly made in people aged 30–60 years. Women are affected slightly more often than men.
Suspect Meniere's disease if the person has classic symptoms of:
Acute attacks of Meniere's disease:
Perform a complete physical examination. In a person with Meniere's disease:
There are no specific diagnostic tests for Meniere's disease, therefore the diagnosis is based on the presence of key clinical features. Refer to ENT for confirmation of diagnosis.
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Biochemistry | Normal Value |
---|---|
Sodium | 135 – 145 mmol/l |
Potassium | 3.0 – 4.5 mmol/l |
Urea | 2.5 – 7.5 mmol/l |
Glucose | 3.5 – 5.0 mmol/l |
Creatinine | 35 – 135 μmol/l |
Alanine Aminotransferase (ALT) | 5 – 35 U/l |
Gamma-glutamyl Transferase (GGT) | < 65 U/l |
Alkaline Phosphatase (ALP) | 30 – 135 U/l |
Aspartate Aminotransferase (AST) | < 40 U/l |
Total Protein | 60 – 80 g/l |
Albumin | 35 – 50 g/l |
Globulin | 2.4 – 3.5 g/dl |
Amylase | < 70 U/l |
Total Bilirubin | 3 – 17 μmol/l |
Calcium | 2.1 – 2.5 mmol/l |
Chloride | 95 – 105 mmol/l |
Phosphate | 0.8 – 1.4 mmol/l |
Haematology | Normal Value |
---|---|
Haemoglobin | 11.5 – 16.6 g/dl |
White Blood Cells | 4.0 – 11.0 x 109/l |
Platelets | 150 – 450 x 109/l |
MCV | 80 – 96 fl |
MCHC | 32 – 36 g/dl |
Neutrophils | 2.0 – 7.5 x 109/l |
Lymphocytes | 1.5 – 4.0 x 109/l |
Monocytes | 0.3 – 1.0 x 109/l |
Eosinophils | 0.1 – 0.5 x 109/l |
Basophils | < 0.2 x 109/l |
Reticulocytes | < 2% |
Haematocrit | 0.35 – 0.49 |
Red Cell Distribution Width | 11 – 15% |
Blood Gases | Normal Value |
---|---|
pH | 7.35 – 7.45 |
pO2 | 11 – 14 kPa |
pCO2 | 4.5 – 6.0 kPa |
Base Excess | -2 – +2 mmol/l |
Bicarbonate | 24 – 30 mmol/l |
Lactate | < 2 mmol/l |