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Questions Answered: 97

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Ophthalmology

Question 54 of 97

A 54 year old man presents to the Emergency Department with diplopia. On examination you note ptosis of the right eye. The right eye is abducted and depressed at rest, with a fixed dilated pupil. A CT angiogram shows a cerebral aneurysm. Aneurysmal disease of which blood vessel is most likely to cause this patient's symptoms?

Answer:

The patient has signs of an oculomotor nerve palsy. Posterior communicating artery aneurysms are a cause of this palsy.

Cranial Nerve Palsy

Cranial nerve II: Optic nerve

Cranial Nerve Optic Nerve (CN II)
Key anatomy
  • Formed from convergence of axons of neurons in ganglion layer of retina, surrounded by cranial meninges
  • Enters skull via optic canal of sphenoid bone
  • Receives blood supply from combination of anterior cerebral, ophthalmic and central retinal arteries
Function
  • Sensory: vision
  • Reflexes: afferent pathway of pupillary light reflex, afferent pathway of accomodation reflex
Assessment
  • Visual acuity (Snellen chart)
  • Colour vision (Ishihara plates)
  • Pupillary light response
  • Accomodation reflex
  • Optic disc (fundoscopy)
  • Visual fields
Clinical effects of injury
  • Ipsilateral monocular visual loss
  • Loss of colour vision
  • Abnormal pupillary light reflex
  • Visual field defect if damage to visual pathway
Causes of injury
  • Optic neuritis in multiple sclerosis
  • Optic nerve compression in orbital cellulitis, glaucoma, tumours
  • Optic nerve toxicity secondary to poisoning e.g. alcohols
  • Trauma e.g. orbital fracture, penetrating injury to eye
  • Ischaemia secondary to vascular disease

Cranial nerve III: Oculomotor nerve

Cranial Nerve Oculomotor Nerve (CN III)
Key anatomy
  • Arises from midbrain and passes through lateral aspect of cavernous sinus
  • Exits skull through superior orbital fissure
Function
  • Motor: innervates four extraocular muscles (inferior oblique, superior, inferior and medial rectus muscles), levator palpebrae superioris muscle (elevation of upper eyelid), sphincter pupillae muscle (pupillary constriction), ciliary muscle (accommodation)
  • Reflexes: efferent pathway of pupillary light reflex, efferent pathway of accomodation reflex
Assessment
  • Eye movements
  • Accommodation reflex
  • Pupillary light response
Clinical effects of injury
  • Depressed and abducted (down and out) eye at rest
  • Diplopia
  • Ptosis
  • Fixed and dilated pupil with loss of accommodation and abnormal pupillary light reflex
Causes of injury
  • Tumours
  • Aneurysms (carotid or posterior communicating)
  • Subdural or epidural haematoma
  • Trauma
  • Cavernous sinus disease
  • Diabetes mellitus

Cranial nerve IV: Trochlear nerve

Cranial Nerve Trochlear Nerve (CN IV)
Key anatomy
  • Arises from midbrain and travels through lateral aspect of cavernous sinus
  • Exits skull through superior orbital fissure
Function
  • Motor: superior oblique muscle of eye (intorsion, depression and abduction of eye)
Assessment
  • Eye movements
Clinical effects of injury
  • Weakness of downward gaze (difficulty reading/walking downstairs)
  • Vertical diplopia
  • Eye is extorted and may be elevated (patient head tilts to opposite side to compensate)
Causes of injury
  • Idiopathic
  • Trauma
  • Microvasculopathy
  • Cavernous sinus disease
  • Raised intracranial pressure

Cranial nerve VI: Abducens nerve

Cranial Nerve Abducens nerve (CN VI)
Key anatomy
  • Arises from pons and travels through cavernous sinus
  • Exits skull through superior orbital fissure
Function
  • Motor: lateral rectus muscle of eye (abducts eye)
Assessment
  • Eye movements
Clinical effects of injury
  • Convergent squint at rest (eye turned inwards) with inability to abduct eye
  • Horizontal diplopia
Causes of injury
  • Idiopathic
  • Brain tumours
  • Extradural haematoma
  • Cavernous sinus disease
  • Diabetes mellitus
  • Wernicke-Korsakoff syndrome
  • Trauma

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  • Biochemistry
  • Blood Gases
  • Haematology
Biochemistry Normal Value
Sodium 135 – 145 mmol/l
Potassium 3.0 – 4.5 mmol/l
Urea 2.5 – 7.5 mmol/l
Glucose 3.5 – 5.0 mmol/l
Creatinine 35 – 135 μmol/l
Alanine Aminotransferase (ALT) 5 – 35 U/l
Gamma-glutamyl Transferase (GGT) < 65 U/l
Alkaline Phosphatase (ALP) 30 – 135 U/l
Aspartate Aminotransferase (AST) < 40 U/l
Total Protein 60 – 80 g/l
Albumin 35 – 50 g/l
Globulin 2.4 – 3.5 g/dl
Amylase < 70 U/l
Total Bilirubin 3 – 17 μmol/l
Calcium 2.1 – 2.5 mmol/l
Chloride 95 – 105 mmol/l
Phosphate 0.8 – 1.4 mmol/l
Haematology Normal Value
Haemoglobin 11.5 – 16.6 g/dl
White Blood Cells 4.0 – 11.0 x 109/l
Platelets 150 – 450 x 109/l
MCV 80 – 96 fl
MCHC 32 – 36 g/dl
Neutrophils 2.0 – 7.5 x 109/l
Lymphocytes 1.5 – 4.0 x 109/l
Monocytes 0.3 – 1.0 x 109/l
Eosinophils 0.1 – 0.5 x 109/l
Basophils < 0.2 x 109/l
Reticulocytes < 2%
Haematocrit 0.35 – 0.49
Red Cell Distribution Width 11 – 15%
Blood Gases Normal Value
pH 7.35 – 7.45
pO2 11 – 14 kPa
pCO2 4.5 – 6.0 kPa
Base Excess -2 – +2 mmol/l
Bicarbonate 24 – 30 mmol/l
Lactate < 2 mmol/l
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